Associate Professor, Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029
Secondary Affiliation:
Biosafety Level-3 Laboratory (BSL-3), Centralized Core Research Facility (CCRF), All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029
Link to CCRF
Research Interest: Metabolism and bioenergetics of Infectious diseases, Redox Biology,
Mycobacterial infections including HIV-TB co-infections, Nutrition and Virulence,
Genomics and pathogenomics, Gaseous signaling and environmental risk factors for infections, Drug discovery and mechanisms of drug resistance.
Select Publications:
Kumar A, Negi S, Choudhary T, Mutreja V, S Sunaina, Sahoo SC, Singh A, Mehta SK, Kataria R, Saini V (2023).
A highly sensitive and specific luminescent MOF determines nitric oxide production and quantifies
hydrogen sulfide-mediated inhibition of nitric oxide in living cells. Microchimica Acta. PMID: 36897440
*Saini V, Kalra P, Sharma M, Rai C, Saini Vikas, Gautam K, Bhattacharya S, Mani S,
Saini K, Kumar S (2021). A cold chain independent specimen collection and transport
medium improves diagnostic sensitivity, and minimizes biosafety challenges Covid19
molecular diagnosis. Microbiology Spectrum. 9, e01108-21 (2021) Doi:
10.1128/Spectrum.01108-21 $Patent filed.
Research Highlight in Nature India: Microbial transport medium improves COVID-19
diagnostic. https://www.nature.com/articles/d44151-022-00003-x PMID: 34878310
Kumar P, Saini K, *Saini V, *Mitchell T (2021). Oxalate Suppresses macrophage
immunometabolism and anti-bacterial response to uropathogenic E. coli (UPEC)
infection. Frontiers in Immunology. Vol 12, Article 694865. https://doi.org/10.3389/fimmu.2021.694865. PMID: 34745086
Chinta K, Rahman A, Saini V, Glasgow J, Reddy VP et al. (2019) Microanatomic distribution of myeloid Heme Oxygenase-1 protects against free radical-mediated immunopathology in human tuberculosis. Cell Reports, 25 (7), 1938-1952. e5. (Cover page article). PMID: 30428359
Gupta P, Kaur N, Saini V, Bala M, Sherawat S, Gupta S, Dua A, Kumar V, Dutt V, Injeti Elisha, Mittal A. (2019) Cinnamaldehyde regulates H2O 2‐induced skeletal muscle atrophy by ameliorating the proteolytic and antioxidant defense systems. Journal of
Cellular Physiology, 234 (5), 6194-6208. PMID: 30317570
Patel M, Yarlagadda V, Adedoyin O, Saini V, Oreoluwa D, Holmes R, Mitchell T. (2018) Oxalate induces mitochondrial dysfunction and disrupts redox homeostasis in a human monocyte derived cell line. Redox Biology. Vol. 15, 207-215. PMID: 29272854
Dutt V, Saini V, Gupta P, Kaur N, Bala M, Gujar R, Grewal A, Gupta S, Dua A, Mittal A (2018). S-allyl cysteine inhibits TNF alpha induced skeletal muscle wasting through suppressing proteolysis and expression of inflammatory molecules. Biochim Biophys Acta. (Gen Subjects); Vol. 1862 (4): 895-906.
PMID: 29288771
Saini V,Cumming BM, Guidry L, Lamprecht D, Adamson JH, Reddy VP, Chinta KC, Mazorodze J, Glasgow JN, Richard-Greenblatt M, Gomez-Velasco A, Bach H, Av-Gay Y, Eoh H, Rhee K, Steyn AJC (2016). Ergothioneine maintains redox and bioenergetichomeostasis essential for drug susceptibility and virulence of Mycobacterium tuberculosis. Cell Reports. Vol.14, 1-14. PMID: 26774486
Saini V, Raghuvanshi S, Ahmed N, Khurana JP, Hasnain SE, Tyagi Akhilesh K, Tyagi Anil K (2012). Massive gene acquisitions in Mycobacterium indicus pranii provide a perspective on mycobacterial evolution.Nucleic Acids Res. doi: 10.1093/nar/gks793.Vol. 40 (21) 10832-10850. PMID: 22965120
This is the first new bacterial species completely sequenced in India. Selected as a breakthrough article by NAR editorial board representing the top 5% of studies in terms of originality, significance and scientific excellence.
Commentary at Nature: 'Mosaic genome' holds clue to TB, leprosy vaccines
Saini V, Farhana A, Glasgow JN, Steyn AJC (2012). Iron sulfur cluster proteins and microbial regulation: Implications for understanding tuberculosis. Current Opinion in Chemical Biology. Vol. 16 (1-2), 45-53. PMID: 22483328
I would be happy to discuss and sponsor self-motivated, hard-working and bright candidates applying for Post-doctoral fellowships/scientist positions for various funding agencies like DBT/DST and ICMR. Interested candidates should contact by email along with a 1-page write-up, CV and 3 references.
